Non‐viral nucleic acid delivery to the central nervous system and brain tumors
نویسندگان
چکیده
منابع مشابه
Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System
With an increased prevalence and understanding of central nervous system (CNS) injuries and neurological disorders, nucleic acid therapies are gaining promise as a way to regenerate lost neurons or halt disease progression. While more viral vectors have been used clinically as tools for gene delivery, non-viral vectors are gaining interest due to lower safety concerns and the ability to deliver...
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Background & Objectives: The accurate assessment of the diseased tissue is fundamental to the diagnosis and management of disorders of the central nervous system (CNS). The ‛squash’ or ‛crush’ technique has been universally employed in the intraoperative diagnosis of CNS tumors. The aim of our study was to evaluate the accuracy of squash preparation in diagnosing CNS tumors by comparing with hi...
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Central nervous system tumors are relatively common in the United States, with more than 40,000 cases annually. Although more than half of these tumors are benign, they can cause substantial morbidity. Malignant primary brain tumors are the leading cause of death from solid tumors in children and the third leading cause of death from cancer in adolescents and adults aged 15 to 34 years. Common ...
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Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...
متن کامل[Metastatic tumors of the central nervous system].
This scholarly work has been produced by four Japanese neuroscientists, two neurosurgeons and two neuropathologists. It is a very detailed study of the laboratory and clinical aspects of metastatic tumours in the central nervous system, based mainly on large personal series. The authors carefully analyse the massive amount of data involved, as well as review thoroughly the world literature of t...
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ژورنال
عنوان ژورنال: The Journal of Gene Medicine
سال: 2019
ISSN: 1099-498X,1521-2254
DOI: 10.1002/jgm.3091